منابع مشابه
Clozapine resistance: augmentation strategies.
BACKGROUND Clozapine (CLZ) is not effective in more than 50% of treatment-resistant schizophrenic patients. In these cases, several pharmacological strategies are used in clinical practice, with different levels of evidence for both safety and efficacy. OBJECTIVES In the present paper we critically reviewed literature data regarding the efficacy and safety of adjunctive agents in CLZ-resistan...
متن کاملWhen symptoms persist: clozapine augmentation strategies.
Recent data and clinical experience confirm that, in spite of superior efficacy for treatment-refractory schizophrenia, a substantial proportion of patients receiving clozapine will continue to experience disabling symptoms. Optimizing clozapine monotherapy is the first step in the management of "clozapine nonresponders." Described here is a synthesis of the available literature on the range an...
متن کاملClozapine augmentation with amisulpride.
A 42-year-old man with treatmentresistant schizophrenia presented a progressive clinical worsening under clozapine treatment (450 mg/d). He experienced worsening auditory hallucinations, increased distress and decreased working and social functioning (Positive and Negative Syndrome Scale [PANSS] score 97; positive subscale 21; negative subscale 31; general subscale 45). He experienced several s...
متن کاملRisperidone Augmentation of Clozapine
Sir, Henderson and Goff (1996) in an open trial reported augmentation of clozapine's effect with risperidone in schizophrenic patients not responding to clozapine alone. There are no reports in literature of controlled trials or on long term effectiveness of this combination. In this report a case has been described which shows the long term effectiveness of this combination in resistant schizo...
متن کامل[Augmentation strategies in patients with schizophrenia who show partial response to clozapine treatment].
A significant proportion of patients with schizophrenia receiving clozapine remain with partial response. In this group of patients findings regarding addition of various psychotropics to ongoing clozapine treatment for augmentation are controversial. In this review, literature regarding the efficacy and safety of adjunctive agents in clozapine resistant schizophrenic patients is examined. Augm...
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ژورنال
عنوان ژورنال: Mental Health Clinician
سال: 2019
ISSN: 2168-9709
DOI: 10.9740/mhc.2019.11.336